Domperidone/Motilium: A Commentary

Not considering a woman's individual ability to cope with stress, would seem to be a major flaw in this study. While overall results of this study were positive, because of this flaw, the optimal effectiveness of 30 mg of Domperidone per day as a galactagogue would have to be considered inconclusive.

From personal experiences of women who have successfully used Domperidone as a galactagogue, a de-facto dosage has emerged. Women who have successfully induced lactation using Domperidone as an aid, often recommend two, 10 mg tablets of Domperidone, 4 times daily, (total of 80 mg per day). There is also a general consensus that Domperidone should be taken for at least six months before attempting to wean one's self from the drug.

Myths Of Domperidone:
As with many things in life, many commonly accepted "facts" about Domperidone are in reality: myths!

Myth:

Domperidone has a cumulative effect in the female body, and must be taken long term to effectively induce and maintain lactation.

Fact:

Manufacturer's laboratory tests have shown: one, 30 mg tablet of Domperidone can increase Prolactin levels in the female bloodstream by as much as 1300%. An adequate level of Prolactin to stimulate mammary glands into milk production. If Domperidone is going to work as an effective aid for inducing lactation, it will work from the first dose.

Domperidone induces lactation by blocking Dopamine receptors at the Pituitary gland. When Domperidone reaches the Dopamine receptors at the Pituitary gland, the effects are immediate. There is no accumulative effect: increased Prolactin secretion begins within 90 minutes of ingesting the first dose.

Fact:

Domperidone does not need to be taken long term to induce and maintain lactation. In fact, the opposite is actually true! While Domperidone does dramatically increase Prolactin secretion from the first dose, by the 14th dose, Prolactin levels in the female bloodstream suddenly drop by 50%.

Manufacturer's laboratory tests have shown: the first dose of Domperidone will elevate Prolactin levels in the female bloodstream to as much as 117 nanograms of Prolactin per milliliter of blood. However, the same tests also discovered, by the 14th dose Prolactin levels suddenly drop to 56 nanograms of Prolactin per milliliter of blood.

While 117 ng/mL of Prolactin is adequate to start and maintain lactation, 56 ng/mL for many women is not! It is not uncommon to find a woman who is overjoyed by the effectiveness of Domperidone on the first day, only to find her disheartened by the fifth day when her gains have suddenly disappeared.

It is common for a woman's body to become partially resistant to Domperidone by the fifth day.

If you are using Domperidone to induce lactation, and you are able to maintain or increase your milk supply beyond the fifth day, it is because your body's natural ability to lactate has taken over milk production. After the fifth day, Domperidone has only minimal effectiveness on lactation.

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